The FAB system, based on peripheral blood and bone marrow morphology, defined 5 morphologic categories that represent a transition between myelodysplasia syndrome and AML.Īlthough many of the features observed in childhood myelodysplasia syndrome are similar to those in the adult form of the disease, unique differences are also noted, especially when children lack blasts in the peripheral blood or bone marrow. 1979 Harvey 1981 Raskin and Kxehbiel 1985) but to our knowledge MDS has not been reported in the horse.The 2001 World Health Organization (WHO) classification system incorporated cytogenetics into the the French-American-British (FAB) cooperative group morphologic classification system for adult myelodysplasia syndrome. Cases of MDS have been described in dogs (Couto and Kallet 1984 Weiss et al. 1985), but regardless of whether transformation occurs, the mortality associated with MDS is high (Vallespi et al. Some types of MDS in people have a high propensity to evolve into AML (Rosenthal and Moloney 1984 Vallespi et al. 1982 Rosenthal and Moloney 1984 Koeffler 1986 Bagby 1985a). Keywords: horse rnyelodysplasia Introduction The myelodysplastic syndromes (MDS) are a heterogeneous group of disorders characterised by peripheral cytopenias, dysplastic changes in erythroid, myeloid and/or megakaryocytic cell lines, and an increased number of immature haematopoietic cells in the bone marrow, without sufficient numbers of blast cells to be termed an acute myeloid leukaemia (AML) (Bennett et al. HARVEYt Departments of Large Animal Clinical Sciences and Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.
Myelodysplastic syndrome in a Quarter Horse gelding MARY M. This report describes a horse with MDS in which dyserythropoiesis 1979 Harvey 1981 Raskin and Kxehbiel 1985) but to our knowledge MDS has not been reported in the horse. Myelodysplasie syndrome in a Quarter Horse gelding Myelodysplasie syndrome in a Quarter Horse geldingĭURANDO, MARY M.